报告题目：From single-cell based modeling to population dynamics

报告时间：2021年7月12日，星期一，下午2:30-5:30

腾讯会议ID：413 865 431

密码：210712

报告人：雷锦志教授，天津工业大学数学科学学院

报告摘要：

In understanding the evolution process of a multicellular system, it is challenging issue to establish the relationship that connects the microscopic state of individual cells with the macroscopic population dynamics. In this talk, I will introduce a framework of individual-cell based computational modeling and the related mathematical model. Moreover, in order to describe the dynamics of intrinsic state of individual cells, we introduce the concept of single-cell entropy (scEntropy) based on single cell RNA sequencing data, which can be used to describe the order parameter of gene expressions in a single cell. The main point of this talk is trying to establish a connection between microscopic information and macroscopic states in multicellular systems.  

报告人简介：

  雷锦志，天津工业大学数学科学学院、应用数学中心教授，博士生导师，天津市特聘教授。长期从事计算生物学、生物信息学、动力系统等领域的研究工作，在癌症演变动力学、干细胞增殖的多尺度建模等领域取得一系列研究成果，提出原创的异质性干细胞增殖过程数学模型框架。主要研究方向为计算数学、计算系统生物学、生物数学。到目前共发表SCI论文60余篇，研究论文发表于PNAS, Phy Rev Lett, Cancer Research, J Theor Biol, SIAM J Math Anal, J Diff Equ等国际期刊，被引用600 多次，出版了一本系统生物学著作，主持国家自然科学基金项目四项，受邀参加2019年国际生物数学大会(SMB2019)并做大会报告。