讲座题目：Quantification of transcription noise's impact on cell fate commitment with digital resolutions

讲座时间：2022年5月25日（周三），下午19：30-21：30（北京时间）

腾讯会议：290-453-596 ，密码：0525

报告人: 焦锋副教授，广州大学

报告摘要：

Gene transcription is a random and noisy process. Tremendous efforts in single cell studies have been mapping transcription noises to phenotypic variabilities between isogenic cells. However, the exact role of the noise in cell fate commitment remains largely descriptive or even controversial. For a specified cell fate, we define the jumping digit I of a critical gene as a statistical threshold that a single cell has approximately an equal chance to commit the fate as to have at least I transcripts of the gene. When the transcription is perturbed by a noise enhancer without changing the basal transcription level E_0, we find a crossing digit k such that the noise catalyzes cell fate change when I>k while stabilizes the current state when I<k; k remains stable against enormous variations of kinetic rates. We further test the reactivation of latent HIV in 22 integration sites by noise enhancers paired with transcriptional activators. Strong synergistic actions are observed when the activators increase transcription burst frequency, whereas no synergism, but antagonism, is often observed if activators increase burst size. The synergistic efficiency can be predicted accurately by the ratio I /E_0. When the noise enhancers double the noise, the activators double the burst frequency, and I /E_0>7, their combination is 10 times more effective than their additive effects across all 22 sites.

报告人简介： 

     焦锋，副教授，广州大学数学与信息科学学院副院长，从事常微分方程定性理论及其应用研究。近年来围绕随机基因表达的数学刻画开展了生物数学的方法研究及其在分子生物学层面的应用。目前已在《Bioinformatics》,《Biophysical J.》，《PLoS Comput. Biol.》，《SIAM J. Appl. Math.》，《Phys. Rev. E》，《J. Differential Equations》等SCI刊物发表论文30余篇，SCI被引1600余次；先后主持国家自然科学基金面上项目和青年基金，广东省自然科学基金面上项目和青年项目；参与国家级重点、重大研究平台项目，是教育部创新团队的核心成员；获湖南省自然科学奖二等奖（第三）。